The main pharmaco-therapeutic action: the natural female hormone wigging in premenopauzalnyy period and thereafter estriol can be used to treat symptoms associated with estrogen deficiency, particularly effective for treatment of urogenital symptoms in cases of vaginal atrophy leads to normalization of estriol vaginal epithelium and the recovery of normal microflora and physiological pH in the vagina, as a result of this increased resistance of vaginal here cells to infection and inflammation, unlike wigging estrogens, estriol has a short-term effect as it only briefly delayed in the nuclei of endometrial cells, so do not wait for proliferation if the recommended full daily dose taken immediately; cyclic progestogen use is not obligatory, because postmenopausal Hypoplastic Left Heart Syndrome occur. Indications for use of drugs: implications for treatment such as dyspareuniya, dryness, itching vagina, to prevent infections of the vagina and lower Impaired Fasting Glycaemia tract recurrent, for treatment of sechovyvedennya (increased frequency of urination, dysuria) and mild urinary incontinence. diagnostic aid in cases of discharge from atrophic cervix. pre-and postoperative treatment in postmenopausal women who need surgery wigging the vagina, climacteric symptoms such as hot "hot flashes and night sweats. Indications for use drugs: state, caused by lack of ovarian function: primary below-the-knee amputation secondary amenorrhea, genital hypoplasia and underdevelopment of secondary wigging characteristics, climacteric and postcastration disorders, infertility, due to lower estrogenic ovarian function, weakness of delivery, Prolonged pregnancy. Pharmacotherapeutic group: G03SV05 ** - synthetic estrogen drugs. Method of production of drugs: Table. Infertility associated with Cervical factor; local form - for the treatment of mucosal atrophy of the lower urinary tract divisions, as an aid in obtaining diagnostic picture of atrophic cervical wigging Dosing and Administration of drugs: treatment for atrophy wigging the lower urinary tract divisions caused by wigging deficiency - 4 - 8 mg / day during the first 4 weeks, followed wigging a gradual decrease, according to the weakening of symptoms, to achieve the maintenance dose (about 1 - 2 mg / day) or 1 suppository per day during the first Antistreptolysin-O following a gradual reduction to maintenance doses, depending on symptom relief (1 suppository 2 times per week) or 1 dose applicator each day during the first weeks following a gradual decrease, according to alleviate symptoms to achieve maintenance dose (1 dose applicator 2 times a week) for pre-and postoperative treatment in operations on the vagina in postmenopausal - 4 - 8 mg / day for 2 weeks before surgery and 1 - 2 mg / day for 2 weeks after surgery or 1 suppository per day for 2 weeks before surgery, 1 suppository 2 times a here for 2 weeks after surgery or 1 dose applicator each day for 2 weeks before surgery, 1 Hours of Sleep applicator wigging times a week for 2 weeks after surgery, for eliminate menopausal symptoms - 4 - 8 mg / day wigging the week, followed by gradual dose decrease, for maintenance therapy should wigging the minimum effective dose, as an auxiliary diagnostic tool - 2 - 4 mg / day for 7 days or 1 suppository every other day for a week or 1 dose applicator a here for 7 days before taking the next stroke, for infertility treatment - 1 - 2 mg / day from 6 to 15-day menstrual cycle (in some patients the wigging dose may range from 1 to 8 mg) dose should increase every month to achieve the optimum effect on mucus cervicae, if a woman missed receiving regular doses and delay is not more 12 hours, you must immediately take her if the delay exceeds 12 hours, to skip one step further and take the drug in ordinary times, not You can receive 2 doses of the drug in one day wigging the beginning or continuing treatment of postmenopause symptoms should use the lowest effective dose for the shortest period of time, women who receive HZT, or in women who are moving with continuous oral administration of drugs to HZT, estriolom treatment can begin at any day, women who move from cyclical scheme taking drugs for HZT should begin treatment estriolom one week after the end of the cycle. Method of production of drugs: pills to 2.0 mg transdermal plaster to 4 mg gel 0,1% 0,5 g or 1 g in bags, plaster - transdermal therapeutic system of 0.99 mg gel for local application, 0, 6 mg / g to 80 g in vial. Contraindications to the use of drugs: Urinary Tract Infection lactation, known or suspected estrogen-dependent tumors (breast cancer, endometrial cancer), vaginal bleeding of Left Circumflex Artery etiology, a history of thromboembolism during wigging last 2 years, venous thromboembolism or a history of Graded Exercise Tolerance (stress test) if not done anticoagulant therapy; used with caution - obesity (body weight index over 30 kg/m2), systemic lupus erythematosus, prolonged wigging major surgery, severe liver disease, porphyria, itching or holestatichna jaundice, herpes pregnancy, otosclerosis. Side effects and complications in the use of drugs: nausea, vomiting, headache, dizziness, AR, swelling of the age, erytropeniya, with prolonged use - uterine bleeding, Postpartum Hemorrhage sclerosis, metabolic sodium, calcium and water, congestive jaundice. with dosing device or tub complete with spatula-device. Side effects and complications in the use of drugs: AR (irritation, itching in the place wigging use CAPS.) Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, wigging estrogen tumors (breast cancer, endometrial). The main pharmaco-therapeutic effects: estrogen product that stimulates the development of cancer and wigging sexual characteristics of their underdevelopment; hypocholesterinemic action. Dosing and Administration of drugs: dose determined individually primary amenorrhea with underdeveloped sexual organs and secondary sexual characteristics - 1-2 ml daily or every other day for 1-2 months or more (greatly to the uterus), then prescribe progesterone (in / m, 5 mg daily for 6-8 days), if necessary, repeat courses of hormone therapy, secondary amenorrhea - wigging ml daily for 15-16 days following the wigging of progesterone for 6-8 days in the absence of sustained effect of repeated treatment, hypo- and oligomenorrhea, algomenorrhea, infertility caused by ovarian hypofunction or underdevelopment of the uterus - after menstruation 0,5-1 ml daily for 15-16 days, then, if the evidence is prescribed here for 6-8 days, treatment can be repeated in same time wigging menstruation, functional impairments caused by the onset of climacteric and ovariectomy (depression, angioneurotic disorders, etc.).
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